Synthesis of α-Aminophosphonates with Nano Fe₃O₄

Significance

Fe₃O₄ nanoparticles promoted the reaction of carbonyl compounds 1, amines 2, and diethyl phosphate 3 under solvent-free conditions to achieve a one-pot synthesis to form α-aminophosphonates 4 within less than one hour in 76-94% yield (21 examples). For the formation of 4a, the catalyst was magnetically recovered and reused ten times without significant loss of activity (1^st reuse: 94%; 2^nd reuse: 92%; 10^th reuse: 86%).