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Synfacts 2011(5): 0570-0570  
DOI: 10.1055/s-0030-1259815
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Cyanosilylation with a Polymeric Chiral Titanium Complex

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Aya Ohno
S. Sakthivel, T. Punniyamurthy*
Indian Institute of Technology Guwahati, India
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Publikationsverlauf

Publikationsdatum:
15. April 2011 (online)

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Significance

Chiral linear polymer-supported Ti complex 3 was prepared and applied to the asymmetric cyanosilylation of aldehydes. Thus, the ­reaction of aryl aldehydes with TMSCN gave the corresponding cyanohydrins in 90-97% yield with 50-88% ee. Aliphatic aldehydes also underwent cyanosilylation to afford the corresponding products in 90-95% yield with 40-66% ee.