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Synfacts 2011(5): 0509-0509  
DOI: 10.1055/s-0030-1259830
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Intramolecular Hydroamination of Alkenes

Contributor(s): Mark Lautens, Jane Panteleev
K. Manna, S. Xu, A. D. Sadow*
Iowa State University, Ames, USA
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Publikationsverlauf

Publikationsdatum:
15. April 2011 (online)

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Significance

The authors describe a zirconium-catalyzed enantioselective hydroamination of ­alkenes. This is a convenient strategy to access chiral amine building blocks from linear precursors (see Review below). The catalyst system is noteworthy for high reactivity at low temperatures (r.t. or even -30 ˚C), and the observed enantioselectivities are high for hydroamination with unprotected amines.