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Synfacts 2011(5): 0530-0530
DOI: 10.1055/s-0030-1259869
DOI: 10.1055/s-0030-1259869
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed Asymmetric Hydrogenation of Aryl Ketones
T. Irrgang, D. Friedrich, R. Kempe*
University of Bayreuth and AIKAA-Chemicals GmbH, Bayreuth, Germany
Further Information
Publication History
Publication Date:
15 April 2011 (online)
Significance
This report describes a chiral phosphine-free amido-iridium complex for asymmetric hydrogenation of ketones. Various aryl ketones are successfully hydrogenated in greater than 99% ee and very high conversion. The selectivities are comparable to or better than other chiral metal catalytic hydrogenation systems.