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Synfacts 2011(5): 0523-0523  
DOI: 10.1055/s-0030-1259877
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Rhodium-Catalyzed Hydrogenation of α-Dehydroamino Ketones

Contributor(s): Hisashi Yamamoto, Dmitry L. Usanov
T. Sun, G. Hou, M. Ma, X. Zhang*
Rutgers, The State University of New Jersey, Piscataway, USA
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Publikationsdatum:
15. April 2011 (online)

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Significance

Despite the success achieved in hydrogenation of prochiral dehydroamino acids, asymmetric hydrogenation of α-dehydroamino ­ketones has been poorly explored. In this paper, the authors report rhodium-catalyzed hydrogen­ation of these compounds; the reactions proceed with high reactivity (1000 TON) and excellent enantioselectivity (up to 99% ee).