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Synlett 1997; 12(12): 1403-1405
DOI: 10.1055/s-0030-1260179
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© Georg Thieme Verlag KG Stuttgart · New York

An Efficient Synthesis of 4-Aryl and 4-Vinylphenylalanines by Stille Cross-Coupling Reaction

Enrico Morera, Giorgio Ortar
  • Dipartimento di Studi Farmaceutici, Università “La Sapienza”, 00185 Roma, Italy, Fax: +39 (6) 491491; e-mail: ortar@axrma.uniroma1.it
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Publication History

Publication Date:
19 September 2011 (online)

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Abstract

The palladium-catalyzed reaction of N-Boc-4-trimethyl-stannyl-L-phenylalanine methyl ester (1) with a variety of aryl and vinyl iodides and triflates (2) affords the corresponding 4-aryl and 4-vinylphenylalanines 3 in synthetically useful yields.

Key words

amino acids - organostannanes - palladium catalysis - cross-coupling reaction