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Synfacts 2011(8): 0894-0894
DOI: 10.1055/s-0030-1260729
DOI: 10.1055/s-0030-1260729
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Base-Free Oxidative Heck Reaction
A. L. Gottumukkala, J. F. Teichert, D. Heijnen, N. Eisink, S. van Dijk, C. Ferrer, A. van den Hoogenband, A. J. Minnaard*
University of Groningen and Abbott Healthcare Products B.V., Weesp, The Netherlands
Further Information
Publication History
Publication Date:
20 July 2011 (online)
![](https://www.thieme-connect.de/media/synfacts/201108/lookinside/thumbnails/10.1055-s-0030-1260729-1.jpg)
Significance
In this work, a novel catalytic system for a base-free oxidative Heck reaction is described. With the bis-imine acenaphthenequinone ligand, even sensitive Heck acceptors such as aldehydes could be selectively arylated with dioxygen as oxidant. The steric bulk of the ligand suppresses biaryl formation and the reaction thus proceeds smoothly at room temperature with dioxygen as the oxidant.