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Synfacts 2011(8): 0894-0894  
DOI: 10.1055/s-0030-1260729
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Base-Free Oxidative Heck Reaction

Contributor(s): Paul Knochel, Thomas Kunz
A. L. Gottumukkala, J. F. Teichert, D. Heijnen, N. Eisink, S. van Dijk, C. Ferrer, A. van den Hoogenband, A. J. Minnaard*
University of Groningen and Abbott Healthcare Products B.V., Weesp, The Netherlands
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Publikationsdatum:
20. Juli 2011 (online)

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Significance

In this work, a novel catalytic system for a base-free oxidative Heck reaction is described. With the bis-imine acenaphthenequinone ligand, even sensitive Heck acceptors such as ­aldehydes could be selectively arylated with dioxygen as oxidant. The steric bulk of the ligand suppresses biaryl formation and the reaction thus proceeds smoothly at room temperature with ­dioxygen as the oxidant.