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Synfacts 2011(8): 0853-0853
DOI: 10.1055/s-0030-1260735
DOI: 10.1055/s-0030-1260735
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Cooperative Transition-Metal and Chiral Brønsted Acid Catalysis
S. Zhou, S. Fleischer, K. Junge, M. Beller*
Leibniz-Institut für Katalyse an der Universität Rostock, Germany
Further Information
Publication History
Publication Date:
20 July 2011 (online)
Significance
The authors report a protocol for the enantioselective hydrogenation of various ketimines in the presence of a chiral Brønsted catalyst and a well-defined nonchiral iron catalyst. This work demonstrates that enantioselective reduction reactions with hydrogen can be performed without employing precious-metal catalysts and chiral ligands yielding products with high yields and enantioselectivities.