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Synfacts 2011(8): 0818-0818  
DOI: 10.1055/s-0030-1260751
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of DC-45-A2

Contributor(s): Steven V. Ley, Philippa B. Cranwell
J. Švenda, N. Hill, A. G. Myers*
Harvard University, Cambridge, USA
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Publication History

Publication Date:
20 July 2011 (online)

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Significance

The trioxacarcins are a diverse class of natural products that have potential for the treatment of human cancer cell lines. To date, 20 trioxacarcins have been characterized and all are very closely related in structure to the natural product DC-45-A2. In order to further investigate the potential of the trioxacarcins as anticancer agents, an efficient route to DC-45-A2 was sought to provide access to quantities sufficient for biological evaluation.