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Synfacts 2011(8): 0818-0818
DOI: 10.1055/s-0030-1260751
DOI: 10.1055/s-0030-1260751
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of DC-45-A2
J. Švenda, N. Hill, A. G. Myers*
Harvard University, Cambridge, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Juli 2011 (online)
Significance
The trioxacarcins are a diverse class of natural products that have potential for the treatment of human cancer cell lines. To date, 20 trioxacarcins have been characterized and all are very closely related in structure to the natural product DC-45-A2. In order to further investigate the potential of the trioxacarcins as anticancer agents, an efficient route to DC-45-A2 was sought to provide access to quantities sufficient for biological evaluation.