Asymmetric Alkynylation of α-Trifluoromethyl Ketoimine
Esters

G. Huang; J. Yang; X. Zhang

doi:10.1055/s-0030-1260827

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Synfacts 2011(8): 0867-0867
DOI: 10.1055/s-0030-1260827

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Asymmetric Alkynylation of α-Trifluoromethyl Ketoimine Esters

Contributor(s): Hisashi Yamamoto, Patrick Brady
G. Huang, J. Yang, X. Zhang*
Shanghai Institute of Organic Chemistry, P. R. of China

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Publication History

Publication Date:
20 July 2011 (online)

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Significance

The authors describe an asymmetric alkynylation of α-CF₃ ketoimines using a zinc/BINOL-catalyzed process. A wide range of alkyne coupling partners is able to undergo the addition, generating the product with high asymmetric induction.