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Synfacts 2011(9): 0984-0984  
DOI: 10.1055/s-0030-1260906
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Lithium Binaphtholate-Catalyzed Asymmetric Alkynylation of Ketones

Contributor(s): Hisashi Yamamoto, Patrick Brady
K. Tanaka, K. Kukita, T. Ichibakase, S. Kotani, M. Nakajima*
Kumamoto University, Japan
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Publikationsdatum:
19. August 2011 (online)

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Significance

The authors describe an asymmetric lithium binaphtholate catalyzed alkynylation of ketones. The simplicity of this method and the ready availability of the reagents and catalyst make this procedure particularly attractive.