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Synfacts 2011(9): 0931-0931  
DOI: 10.1055/s-0030-1260927
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Cyanolide A Aglycon

Contributor(s): Steven V. Ley, Catherine F. Carter
M. R. Gesinski, S. D. Rychnovsky*
University of California, Irvine, USA
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Publikationsverlauf

Publikationsdatum:
19. August 2011 (online)

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Significance

Cyanolide A is a C 2-symmetrical macrolide isolated from the cyanobacteria Lyng­bya bouillonii. Previous syntheses have employed lactonization protocols to furnish the macrocyclic ring. The dimerization strategy employed here ­facilitates a concise synthesis requiring only ten steps.