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Synfacts 2011(10): 1045-1045  
DOI: 10.1055/s-0030-1261143
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Isatisine A

Contributor(s): Steven V. Ley, James R. Frost
X. Zhang, T. Mu, F. Zhan, L. Ma, G. Liang*
Nankai University, Tianjin, P. R. of China
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Publikationsdatum:
20. September 2011 (online)

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Significance

(-)-Isatisine A was isolated by Chen and co-workers in 2007 from the leaves of Isatis indigotica Fort. (Cruciferae) with (-)-isatisine A ­acetonide, an artifact of the isolation process. The latter has shown to be cytotoxic against C8166 cell line and demonstrates anti-HIV-1IIIB activity. It is speculated that (-)-isatisine A exhibits stronger activity than its derivative, although limited amounts of natural material have prevented biological testing.