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DOI: 10.1055/s-0030-1261177
The Origins of Nucleotides
Publikationsverlauf
Publikationsdatum:
10. August 2011 (online)
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Abstract
The origins of life represent one of the most fundamental chemical questions being addressed by modern science. One of the longstanding mysteries of this field is what series of chemical reactions could lead to the molecular biologists dream; a pool of homochiral nucleotides? Here we summarize those results we consider to be historically important and outline our recently published research aimed at understanding the chemoselective origins of the canonical ribonucleotides.
1 Introduction
1.1 Nucleotides: What’s the Problem?
2 Synthesis of Activated Pyrimidines
2.1 Pyrimidine Elaboration by Cyanovinylation
2.2 Photochemical Epimerization and Cytidine to Uridine
Conversion
2.3 Urea-Mediated Phosphoryl Transfer and Intramolecular
Rearrangement
2.4 Pyrimidine Photosanitization
3 Chemoselective Purine Glycosylation
4 Future Scope for Investigation
5 Conclusion
Key words
nucleotides - chemoselectivity - multicomponent reactions - rearrangement - photochemistry
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