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Synfacts 2011(11): 1222-1222  
DOI: 10.1055/s-0031-1289177
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Ene Reaction by La/Ag Heterobimetallic Cooperative Catalysis

Contributor(s): Hisashi Yamamoto, Patrick Brady
A. Matsuzawa, T. Mashiko, N. Kumagai*, M. Shibasaki*
Institute of Microbial Chemistry, Tokyo and The University of Tokyo, Japan
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Publikationsdatum:
19. Oktober 2011 (online)

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Significance

This report describes an asymmetric Conia-ene reaction catalyzed by a bimetallic system consisting of a hard La(III) and a soft Ag(I) Lewis acid. The functionalized cyclopentane products bearing a quaternary stereogenic center and an exocyclic olefin are obtained with high enantio­selectivity.