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Synfacts 2011(11): 1213-1213  
DOI: 10.1055/s-0031-1289181
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Phosphorus Amidite-Olefin Ligands for Allylic Alkylation of Indoles

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Z. Liu, Z. Cao, H. Du*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China
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Publikationsdatum:
19. Oktober 2011 (online)

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Significance

Optically active indoles, which are commonly found in biologically and medicinally important compounds, are often synthesized through allylic alkylation. The authors here developed a novel phosphorus amidite-olefin ligand for the palladium-catalyzed asymmetric alkylation of indoles.