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Synfacts 2011(11): 1198-1198  
DOI: 10.1055/s-0031-1289185
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

A One-Pot Synthesis of Challenging Chiral Primary Amines

Contributor(s): Hisashi Yamamoto, Susumu Oda
T. C. Nugent*, D. E. Negru, M. El-Shazly, D. Hu, A. Sadiq, A. Bibi, M. N. Umar
Jacobs University Bremen, Germany
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

The conventional synthetic methods for the synthesis of primary amines require multiple steps and harsh nitrogen deprotection conditions, which lead to low overall yield. The authors described a one-pot synthesis of chiral primary amines through an asymmetric reductive amination-hydrogenolysis sequence. In spite of their low reactivity, they achieved the synthesis of ortho-substituted phenylethyl amines in good yield and with high enantioselectivity.