Ti-Mediated Coupling of Amines with Grignard Reagents

doi:10.1055/s-0031-1289192

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Synfacts 2011(11): 1232-1232
DOI: 10.1055/s-0031-1289192

Metal-Mediated Synthesis

Ti-Mediated Coupling of Amines with Grignard Reagents

Contributor(s): Paul Knochel, Andreas K. Steib
T. J. Barker, E. R. Jarvo*
University of California, Irvine, USA

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Publication History

Publication Date:
19 October 2011 (online)

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Significance

A novel titanium-mediated amination of Grignard reagents using primary and secondary amines is described. This new reaction proceeds in a one-pot fashion by chlorination of the respective amine and subsequent titanium-mediated cross-coupling with the Grignard reagent.