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Synfacts 2011(11): 1153-1153  
DOI: 10.1055/s-0031-1289268
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Spirastrellolide F Methyl Ester

Contributor(s): Steven V. Ley, Philippa B. Cranwell
S. Benson, M.-P. Collin, A. Arlt, B. Gabor, R. Goddard, A. Fürstner*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
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Publikationsdatum:
19. Oktober 2011 (online)

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Significance

The spirastrellolides are potent anti-mitotic agents. Their mode of action is by ­selective inhibition of the serine/threonine protein phosphatase PP2 A (IC50 ca. 1 nM).