Download PDF
Synfacts 2011(11): 1155-1155  
DOI: 10.1055/s-0031-1289269
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Brevisamide

Contributor(s): Steven V. Ley, James R. Frost
A. T. Herrmann, S. R. Martinez, A. Zakarian*
University of California, Santa Barbara, USA
Further Information

Publication History

Publication Date:
19 October 2011 (online)

    Permissions and Reprints

Significance

(+)-Brevisamide is a metabolite isolated by Wright and co-workers in 2008 from Karenia brevis. It has attracted the attention of numerous research groups due to its functionalized tetrahydropyran core with dienal sidechain and terminal amine subunit, resulting in several total syntheses. The enclosed synthesis focuses on the concept of atom economy.