PDF herunterladen
Synfacts 2011(12): 1275-1275  
DOI: 10.1055/s-0031-1289314
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of PF-04191834

Contributor(s): Philip Kocienski
P. D. de Koning*, L. Murtagh, J. P. Lawson*, R. A. Vonder Embse, S. A. Kunda, W. Kong
Pfizer Global Research and Development Sandwich, UK; Pfizer Global Research and Development, St. Louis, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
18. November 2011 (online)

    Lizenzen und Reprints

Significance

Inhibition of 5-lipoxygenase prevents the formation of various leukotriene pro-­inflammatory mediators and hence provides a ­potential means for the treatment of asthma, ­atherosclerosis, and pain. PF-014191834 is a ­potent and selective inhibitor of 5-lipoxygenase.