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Synfacts 2011(12): 1340-1340  
DOI: 10.1055/s-0031-1289325
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ir(I)-Catalyzed C-H Bond Activation of 2-(Alkylamino)pyridines with Alkenes

Contributor(s): Hisashi Yamamoto, Susumu Oda
S. Pan, K. Endo, T. Shibata*
Waseda University and Waseda Institute for Advanced Study, Tokyo, Japan
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The authors describe the Ir-catalyzed enantioselective C-H bond activation of 2-(alkylamino)pyridines with alkenes. Despite the development of C-H bond cleavage by transition-metal catalysts, sp³ C-H bond activation is still challenging and limited to reactive positions. Herein, a cationic iridium catalyst enabled the first example of enantioselective secondary sp³ C-H activation of a methylene group, which is not at an allylic or benzylic position.