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Synfacts 2011(12): 1336-1336  
DOI: 10.1055/s-0031-1289333
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Catalyst-Controlled Diastereo- and Enantioselective Hydrogenation

Contributor(s): Mark Lautens, Lei Zhang
M. Akashi, N. Arai, T. Inoue, T. Ohkuma*
Hokkaido University, Sapporo and Nippon Soda Co., Ltd., Odawara, Japan
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Publikationsdatum:
18. November 2011 (online)

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Significance

A diastereoselective reduction of aryl ketones catalyzed by ruthenium is reported. Under rapid enolization-protonation of the substrate in the presence of a base, the strong catalyst preference for one out of four possible transition states also successfully rendered a dynamic kinetic resolution.