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Synfacts 2011(12): 1316-1316  
DOI: 10.1055/s-0031-1289336
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Enantioselective Fluorination of Allylic Halides

Contributor(s): Mark Lautens, Lei Zhang
M. H. Katcher, A. Sha, A. G. Doyle*
Princeton University, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The palladium-catalyzed allylic ­fluorination is one of the first methods for the enantio­selective synthesis of branched allylic ­fluorides. ­Following the authors’ recent report on allylic substitution of cyclic allyl chlorides (J. Am. Chem. Soc. 2010, 132, 17402), the methodology was extended to acyclic substrates.