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Synfacts 2011(12): 1265-1265  
DOI: 10.1055/s-0031-1289342
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Ophiobolin A

Contributor(s): Steven V. Ley, Sean Newton
K. Tsuna, N. Noguchi, M. Nakada*
Waseda University, Tokyo, Japan
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Publikationsdatum:
18. November 2011 (online)

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Significance

(+)-Ophiobolin is a naturally occurring sesterterpene isolated from the pathogenic plant fungus Ophiobolus miyabeanus in 1958. It exhibits bioactivity against a range of nematodes, fungi, and bacteria. Herein, the first total synthesis of (+)-ophiobolin is reported.