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Synfacts 2011(12): 1353-1353
DOI: 10.1055/s-0031-1289344
DOI: 10.1055/s-0031-1289344
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Ti-Mediated Tandem Ethylation and Functionalization of Allylic Alcohols
P. P. Das, I. L. Lysenko, J. K. Cha*
Wayne State University, Detroit, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. November 2011 (online)
Significance
A new stereoselective alkylation of allylic alcohols by trapping of the presumed organometallic intermediates with suitable electrophiles has been disclosed. This titanium-mediated reaction proceeds in an SN2′ manner and uses EtMgBr as alkylation reagent and ClTi(Oi-Pr)3 as scavenger for magnesium alkoxides.