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Synfacts 2011(12): 1347-1347
DOI: 10.1055/s-0031-1289352
DOI: 10.1055/s-0031-1289352
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Bridgehead Radicals for Coupling of Oxygenated Carbocycles
D. Urabe, H. Yamaguchi, M. Inoue*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
Herein, a radical-mediated stereoselective coupling method for the assembly of highly oxygenated carbocycles is reported. An α-alkoxy bridgehead radical is used to form linkages between tertiary alkoxy carbon atoms and tertiary or quaternary carbons. This protocol allows the assembly of complex bicyclic molecules to form the two oxygenated ring-structure substrates.