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Synfacts 2011(12): 1338-1338  
DOI: 10.1055/s-0031-1289359
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Tandem 1,4-Addition-Fluorination Sequence

Contributor(s): Mark Lautens, Patrick T. Franke
L. Wang, W. Meng, C.-L. Zhu, Y. Zheng, J. Nie, J.-A. Ma*
Tianjin University and Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The authors report a mild Cu(OTf)2-catalyzed tandem 1,4-addition-fluorination sequence. The protocol tolerates a broad range of acyclic alkylidene β-keto esters affording products with adjacent carbon- and fluorine-substituted quaternary and tertiary stereocenters.