Copper-Catalyzed Tandem 1,4-Addition-Fluorination
Sequence

doi:10.1055/s-0031-1289359

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Synfacts 2011(12): 1338-1338
DOI: 10.1055/s-0031-1289359

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Copper-Catalyzed Tandem 1,4-Addition-Fluorination Sequence

Contributor(s): Mark Lautens, Patrick T. Franke
L. Wang, W. Meng, C.-L. Zhu, Y. Zheng, J. Nie, J.-A. Ma*
Tianjin University and Nankai University, Tianjin, P. R. of China

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Publikationsverlauf

Publikationsdatum:
18. November 2011 (online)

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Significance

The authors report a mild Cu(OTf)₂-catalyzed tandem 1,4-addition-fluorination sequence. The protocol tolerates a broad range of acyclic alkylidene β-keto esters affording products with adjacent carbon- and fluorine-substituted quaternary and tertiary stereocenters.