Download PDF
Synfacts 2011(12): 1332-1332  
DOI: 10.1055/s-0031-1289368
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Catalyzed Asymmetric Tandem Dual Michael Reaction of Dialkylzinc to Enones

Contributor(s): Mark Lautens, Hongqiang Liu
S. Guo, Y. Xie, X. Hu, H. Huang*
Lanzhou Institute of Chemical Physics and Zhejiang University of Technology, Hangzhou, P. R. of China
Further Information

Publication History

Publication Date:
18 November 2011 (online)

    Permissions and Reprints

Significance

In this paper, the authors report an efficient copper-catalyzed asymmetric dual Michael reaction for the construction of multiple contiguous acyclic stereogenic centers in the products with high diastereo- and enantioselectivity. All the reactions were carried out in a 0.5 mmol scale. The protocol allows efficient access to the enantioenriched pyrrolidines with multiple stereocenters.