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Synfacts 2011(12): 1321-1321  
DOI: 10.1055/s-0031-1289384
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Silver-Catalyzed Enantioselective [3+2] Cycloadditions

Contributor(s): Hisashi Yamamoto, Patrick Brady
Y. Yamashita, T. Imaizumi, X.-X. Guo, S. Kobayashi*
The University of Tokyo, Japan
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Publikationsdatum:
18. November 2011 (online)

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Significance

Chiral substituted pyrrolidines are useful building blocks of biologically active compounds. The report describes their synthesis by a highly enantioselective and exo-selective [3+2] cycloaddition catalyzed by a chiral silver complex. This method is highly versatile, tolerating a wide variety of imines and olefins.