Synlett 2012; 23(11): 1559-1563
DOI: 10.1055/s-0031-1291156
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© Georg Thieme Verlag Stuttgart · New York

Cleaving Carbon–Carbon Bonds by the Release of Trifluoroacetate to Remodel Molecules and Assemble Fluorinated Structures

Changho Han
a   Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
,
Eun Hoo Kim
a   Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
,
David A. Colby*
a   Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
b   Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA, Fax: +1(765)4941414   Email: dcolby@purdue.edu
› Author Affiliations
Further Information

Publication History

Received: 12 March 2012

Accepted after revision: 26 April 2012

Publication Date:
11 June 2012 (online)


Abstract

Cleaving carbon–carbon bonds is a significant synthetic challenge. The release of trifluoroacetate presents a powerful force to break these strong bonds. Herein, a brief review of the role of the release of trifluoroacetate in remodeling organic molecules and synthesizing fluorinated compounds is presented.