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Synlett 2012; 23(19): 2746-2748
DOI: 10.1055/s-0032-1317701
DOI: 10.1055/s-0032-1317701
cluster
C–H Bond Functionalization & Synthesis in the 21st Century: A Brief History and Prospectus
Further Information
Publication History
Received: 08 November 2012
Accepted: 09 November 2012
Publication Date:
22 November 2012 (online)
Abstract
Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C–H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C–H bond functionalization.�
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For mechanistic studies, see:
For an example with rhodium, see:
For C–H esterification, see:
For C–H amination, see:
For C–H alkylation, see:
For examples of late-state C–H oxidations:
For seminal examples using allylic C–H oxidation, see: