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Synlett 2013; 24(11): 1448-1454
DOI: 10.1055/s-0033-1338703
letter
© Georg Thieme Verlag Stuttgart · New York

Direct Amination of Phenols under Metal-Free Conditions

Jianzhong Yu
a   Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China   Fax: +86(571)87951895   eMail: wujunwu@zju.edu.cn
,
Yongtao Wang
a   Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China   Fax: +86(571)87951895   eMail: wujunwu@zju.edu.cn
,
Peizhi Zhang
b   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, P. R. of China
,
Jun Wu*
a   Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China   Fax: +86(571)87951895   eMail: wujunwu@zju.edu.cn
› Institutsangaben
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Publikationsverlauf

Received: 16. März 2013

Accepted after revision: 11. April 2013

Publikationsdatum:
17. Mai 2013 (online)

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Abstract

Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols.

Key words

amination - phenols - metal-free - arylamines - carbazoles

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
  • Supporting Information
 

  • References and Notes

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