Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro

Jorge Castillo-Ramirez; Ileabett Echevarría; Janice Santiago; Marianela Pérez-Torres; Mirna Rivera-Claudio

doi:10.1055/s-0033-1338878

Synthesis, Table of Contents

Synthesis 2013; 45(13): 1853-1856
DOI: 10.1055/s-0033-1338878

paper

Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro

Jorge Castillo-Ramirez

^aUniversity of Puerto Rico at Humacao, Chemistry Department, Call Box 860, Humacao 00972, Puerto Rico Fax: +787(850)9448 Email: mirna.rivera@upr.edu

,

Ileabett Echevarría

^bUniversity of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico

,

Janice Santiago

^bUniversity of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico

,

Marianela Pérez-Torres

^bUniversity of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico

,

Mirna Rivera-Claudio*

^aUniversity of Puerto Rico at Humacao, Chemistry Department, Call Box 860, Humacao 00972, Puerto Rico Fax: +787(850)9448 Email: mirna.rivera@upr.edu

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Abstract

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To Dr. Scott E. Denmark in his 60^th birthday’s celebration. With gratitude and best wishes from Dr. Mirna Rivera Claudio.

Abstract

Two new ferrocene acetals were synthesized from a chiral diol in toluene and characterized by a range of spectroscopic techniques. The biological activities of the products were evaluated by using the breast adenocarcinoma cell lines T47D, MCF7, ZR-75-1, MD-MB-468, and MD-MB-231. In comparison with tamoxifen, the ferrocene acetals showed moderate anticancer activity in vitro for the T47D and MCF7 cell lines.

Key words

acetals - organometallic compounds - iron - drugs

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References

References
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