Total Synthesis of (+)-Fusarisetin A: A Biomimetic Approach

Abstract

This article outlines our recent efforts to synthesize (+)-fusarisetin A, a naturally occurring 3-acyltetramic acid, by a route based on a hypothetical biosynthesis. Our research suggests that the biosynthesis of (+)-fusarisetin A might involve the aerobic oxidation of equisetin, possibly mediated by metal oxidants or by photochemically produced reactive oxygen species.

Key words

radical reactions - total synthesis - biosynthesis - heterocycles - polycycles

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