A Facile Access to Piperidine Derivatives via Copper(I)-Catalyzed 1,3-Dipolar [6+3] Cycloadditions of Azomethine Ylides with Fulvenes

Abstract

Enantioenriched heterocyclic piperidines are important structural motifs present in numerous natural products and biologically active molecules. This article outlines our recent efforts to develop a straightforward access to highly functionalized piperidine derivatives with multiple stereogenic centers, in good yields and excellent stereoselectivities, via copper(I)/TF-BiphamPhos-catalyzed asymmetric 1,3-dipolar [6+3] cycloadditions of azomethine ylides with fulvenes.

Key words

asymmetric catalysis - 1,3-dipolar cycloaddition - azomethine ylides - fulvenes - piperidines

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