Synlett 2014; 25(12): 1633-1637
DOI: 10.1055/s-0033-1341160
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© Georg Thieme Verlag Stuttgart · New York

Desymmetrization as a Strategy in Asymmetric Halocyclization Reactions

Ulrich Hennecke*
Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstr. 40, 48149 Münster, Germany   Fax: +49(251)8336523   Email: ulrich.hennecke@uni-muenster.de
,
Michael Wilking
Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstr. 40, 48149 Münster, Germany   Fax: +49(251)8336523   Email: ulrich.hennecke@uni-muenster.de
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Further Information

Publication History

Received: 22 February 2014

Accepted after revision: 17 March 2014

Publication Date:
10 April 2014 (online)


Abstract

Halocyclization reactions such as halolactonization are powerful synthetic methods for the functionalization of alkenes and alkynes. However, asymmetric versions were thought of as difficult reactions and only recently have new asymmetric, organocatalytic halocyclization methods been reported. Herein, we examine a specific strategy for asymmetric halocyclization reactions, desymmetrizing cyclizations, and highlight recent contributions in this area.