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Synlett 2014; 25(16): 2319-2322
DOI: 10.1055/s-0034-1378379
DOI: 10.1055/s-0034-1378379
letter
Synthesis of l-Octaarginine through Microencapsulated Palladium-Catalyzed Allyl Ester Deprotection
Further Information
Publication History
Received: 31 March 2014
Accepted after revision: 03 June 2014
Publication Date:
08 September 2014 (online)
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Abstract
Octaarginine has been described as a molecular transporter. We report a useful synthesis of orthogonally protected l-octaarginine by using a method based on a microencapsulated palladium catalyst. Known palladium-based methods for allyl ester deprotection have been modified to facilitate purification of the unprotected intermediates. This improvement in the purification step has also been tested with a variety of allyl α-amino esters and allyl α,β-unsaturated esters.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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For reports on l-Arg homopolymers as molecular carriers for cellular uptake, see: