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Synlett 2014; 25(20): 2899-2902
DOI: 10.1055/s-0034-1379482
DOI: 10.1055/s-0034-1379482
letter
Copper-Catalyzed Three-Component Tandem Reactions for the Synthesis of β-Carboalkoxy-γ-lactams
Weitere Informationen
Publikationsverlauf
Received: 11. August 2014
Accepted after revision: 22. September 2014
Publikationsdatum:
20. Oktober 2014 (online)
Abstract
β-Carboalkoxy-γ-lactams were synthesized in high yields via copper-catalyzed three-component reactions of α,β-unsaturated dicarboxylate esters, aldimines, and a silane. The reaction proceeds in a tandem manner via conjugate reduction, Mannich reaction, and a subsequent lactamization. The method is attractive with regard to the flexible combination of easily available reactants, the mild conditions, and the high yields. It provides a concise synthetic route to functionalized lactams with a β-ester group.
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References and Notes
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