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Synlett 2014; 25(19): 2743-2747
DOI: 10.1055/s-0034-1379484
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© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed S-Arylation of Benzothiazole with Aryl Iodides under Aqueous Medium: Facile Synthesis of Aryl(2-aminoaryl) Sulfides

Hang Wai Lee
State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85223649932   Email: kf.yung@polyu.edu.hk   Email: fuk-yee.kwong@polyu.edu.hk
,
Ka Fu Yung*
State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85223649932   Email: kf.yung@polyu.edu.hk   Email: fuk-yee.kwong@polyu.edu.hk
,
Fuk Yee Kwong*
State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong   Fax: +85223649932   Email: kf.yung@polyu.edu.hk   Email: fuk-yee.kwong@polyu.edu.hk
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Further Information

Publication History

Received: 13 September 2014
Accepted after revision: 28 September 2014

Publication Date:
21 October 2014 (online)

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Abstract

A simple route for facile access of aryl(2-aminoaryl) sulfide was reported. With the aid of iron(III) chloride catalyst and diamine ligand, benzothiazole was efficiently S-arylated with various aryl iodides (19 examples) in water under air atmosphere. This operationally simple protocol provides aryl(2-aminoaryl) sulfides in moderate to good yields.

Key words

S-arylation - iron - catalysis - benzothiazole - water

Supporting Information

    for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
  • Supporting Information
 

  • References and Notes

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