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Synlett 2016; 27(03): 313-319
DOI: 10.1055/s-0035-1560516
DOI: 10.1055/s-0035-1560516
synpacts
Synthesis of Trifluoromethoxylated (Hetero)Arenes via OCF3 Migration
Further Information
Publication History
Received: 15 September 2015
Accepted: 02 October 2015
Publication Date:
16 November 2015 (online)
Abstract
Incorporation of the OCF3 group into organic molecules, especially aromatic and heteroaromatic compounds, is recognized as one of the major challenges in synthetic organic chemistry. Although many attempts have been made to develop efficient trifluoromethoxylation strategies, most of the current approaches still require use of highly toxic, thermally unstable reagents, or impractical reaction conditions. Herein, we highlight a recent contribution from our group towards the synthesis of (hetero)aryltrifluoromethyl ethers. Our protocol is scalable, operationally simple, and allows an easy access to a wide range of synthetically useful ortho-OCF3 aniline derivatives, as well as functionalized trifluoromethoxylated pyridines and pyrimidines under mild reaction conditions.
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