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Synlett 2016; 27(06): 805-813
DOI: 10.1055/s-0035-1560551
DOI: 10.1055/s-0035-1560551
synpacts
Employing Unnatural Amino Acids in the Preparation of Biooconjugates
Further Information
Publication History
Received: 14 September 2015
Accepted after revision: 04 November 2015
Publication Date:
04 January 2016 (online)
Abstract
The exploitation of unnatural amino acid (UAA) technologies represents an excellent mechanism for the generation of site-specific bioconjugates. Consequently, significant effort has been invested in the advancement of the technology via the integration of novel bioconjugation reactions and the expansion of the set of UAAs that can be employed. Herein, we report the recent developments in the field and highlight advantages and disadvantages of various UAA bioconjugation reactions.
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