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Synlett 2016; 27(08): 1139-1144
DOI: 10.1055/s-0035-1561351
DOI: 10.1055/s-0035-1561351
synpacts
Radical-Mediated Ring-Opening Functionalization of Cyclobutanols: A Shortcut to γ-Substituted Ketones
Weitere Informationen
Publikationsverlauf
Received: 16. Dezember 2015
Accepted after revision: 06. Januar 2016
Publikationsdatum:
04. Februar 2016 (online)
![](https://www.thieme-connect.de/media/synlett/201608/lookinside/thumbnails/st-2015-p0974-sp_10-1055_s-0035-1561351-1.jpg)
Dedicated to Professor Guo-Qiang Lin
Abstract
Cyclobutanols serve as privileged precursors for the preparation of γ-substituted ketones. We highlight recent advances in the radical-mediated ring-opening functionalization of cyclobutanols by fluorination, chlorination, bromination, or azidation, which open up a new vista for the synthesis of ketone derivatives.
1 Introduction
2 Silver-Catalyzed Fluorination, Chlorination, and Bromination of Cyclobutanols
3 Manganese-Catalyzed Azidation of Cyclobutanols
4 Conclusion
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For selected examples, see:
For reviews, see:
For a highlight, see also:
For examples of the formation of Ag(III) through the interaction of Ag(I) with SelectFluor, see:
For examples, see:
For selected reviews, see:
For examples of the oxidation of Mn(III) to Mn(V) by hypervalent iodine reagent, see: