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DOI: 10.1055/s-0035-1561863
Cα–H Oxidations of Amines to Amides: Expanding Mechanistic Understanding and Amine Scope through Catalyst Development
Publikationsverlauf
Received: 21. März 2016
Accepted after revision: 21. April 2016
Publikationsdatum:
13. Mai 2016 (online)
Abstract
This highlight provides a general overview of Cα–H oxidations of amines to form amides. Initial as well as recent examples are reviewed with a particular focus on existing challenges regarding substrate scope and reaction conditions. Finally, one very recently established catalyst system is described in detail which achieves the iron-catalyzed, Cα–H oxidation of amines under mild conditions.
1 Introduction
2 First C–H Oxygenations
3 State of the Art: Oxidations of Primary, Secondary, Cyclic, Benzylic, and Aromatic Amines
4 General Iron-Catalyzed C–H Oxidations under Mild Conditions
5 Conclusions
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References and Notes
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