C_α–H Oxidations of Amines to Amides: Expanding Mechanistic Understanding and Amine Scope through Catalyst Development

Abstract

This highlight provides a general overview of C_α–H oxidations of amines to form amides. Initial as well as recent examples are reviewed with a particular focus on existing challenges regarding substrate scope and reaction conditions. Finally, one very recently established catalyst system is described in detail which achieves the iron-catalyzed, C_α–H oxidation of amines under mild conditions.

1 Introduction

2 First C–H Oxygenations

3 State of the Art: Oxidations of Primary, Secondary, Cyclic, Benzylic, and Aromatic Amines

4 General Iron-Catalyzed C–H Oxidations under Mild Conditions

5 Conclusions

Key words

amides - catalysis - iron - oxidation - amines - biomimetic synthesis

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