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Synlett 2016; 27(15): 2209-2212
DOI: 10.1055/s-0035-1562114
DOI: 10.1055/s-0035-1562114
letter
Zn(OTf)2-Mediated Expeditious and Solvent-Free Synthesis of Propargylamines via C–H Activation of Phenylacetylene
Weitere Informationen
Publikationsverlauf
Received: 23. Februar 2016
Accepted after revision: 10. April 2016
Publikationsdatum:
10. Mai 2016 (online)
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Abstract
Zn(OTf)2-mediated expeditious and solvent-free synthesis of propargylamines via A3 coupling of aldehydes, amines, and phenylacetylene has been described. The described protocol proceeds effectively with variety of substituted benzaldehydes, enolizable aldehyde, and formaldehyde. Recyclability of the catalyst, low catalyst loading, and use of inexpensive catalyst are the key features of the present protocol.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562114.
- Supporting Information