Synthesis 2016; 48(22): 4009-4015
DOI: 10.1055/s-0035-1562492
paper
© Georg Thieme Verlag Stuttgart · New York

Zwitterionic-Type Molten Salt Catalyzed Iodination in Water: Synthesis of Iodoimidazoheterocycles

Susmita Mondal
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
,
Sadhanendu Samanta
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
,
Mukta Singsardar
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
,
Subhajit Mishra
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
,
Shubhanjan Mitra
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
,
Alakananda Hajra*
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India   Email: alakananda.hajra@visva-bharati.ac.in
› Author Affiliations
Further Information

Publication History

Received: 15 April 2016

Accepted after revision: 19 May 2016

Publication Date:
28 June 2016 (online)


Abstract

An environmentally benign protocol for the iodination of imidazoheterocycles has been developed through sp2 C–H bond functionalization with molecular iodine in water at room temperature. The reaction is catalyzed by an imidazole-based zwitterion-type molten salt. A library of iodo-substituted imidazo[1,2-a]pyridines with broad functionality have been synthesized. This methodology is also applicable to imidazo[2,1-b]thiazole and imidazole scaffolds.

Supporting Information