Synlett 2017; 28(06): 684-690
DOI: 10.1055/s-0036-1588398
letter
© Georg Thieme Verlag Stuttgart · New York

A Sulfonylation Reaction: Direct Synthesis of 2-Sulfonylindoles from Sulfonyl Hydrazides and Indoles

Rajjakfur Rahaman
Department of Chemistry, National Institute of Technology Silchar, Silchar-788010, India   eMail: barmanpranjit@yahoo.co.in
,
Pranjit Barman*
Department of Chemistry, National Institute of Technology Silchar, Silchar-788010, India   eMail: barmanpranjit@yahoo.co.in
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 13. Oktober 2016

Accepted after revision: 29. Dezember 2016

Publikationsdatum:
24. Januar 2017 (online)


Zoom Image

Abstract

A metal-free synthesis of 2-sulfonylindole derivatives has been developed through a novel TBHP/I2-mediated coupling of C3/unsubstituted indoles with sulfonyl hydrazides. The reaction utilizes readily available starting materials under mild reaction conditions, providing an alternative and attractive approach to 2-sulfonylindoles with high yields. The developed synthetic procedure is suitable for both N-protected or unprotected indoles.

Supporting Information