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Synlett 2017; 28(06): 684-690
DOI: 10.1055/s-0036-1588398
DOI: 10.1055/s-0036-1588398
letter
A Sulfonylation Reaction: Direct Synthesis of 2-Sulfonylindoles from Sulfonyl Hydrazides and Indoles
Weitere Informationen
Publikationsverlauf
Received: 13. Oktober 2016
Accepted after revision: 29. Dezember 2016
Publikationsdatum:
24. Januar 2017 (online)
Abstract
A metal-free synthesis of 2-sulfonylindole derivatives has been developed through a novel TBHP/I2-mediated coupling of C3/unsubstituted indoles with sulfonyl hydrazides. The reaction utilizes readily available starting materials under mild reaction conditions, providing an alternative and attractive approach to 2-sulfonylindoles with high yields. The developed synthetic procedure is suitable for both N-protected or unprotected indoles.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588398.
- Supporting Information