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Synlett 2017; 28(19): 2577-2580
DOI: 10.1055/s-0036-1588568
DOI: 10.1055/s-0036-1588568
cluster
Chromium-Catalyzed, Regioselective Cross-Coupling of C–O Bonds by Using Organic Bromides as Reactants
We thank the National Natural Science Foundation of China, SCU, and Beijing National Laboratory for Molecular Sciences for financial support.Further Information
Publication History
Received: 01 July 2017
Accepted after revision: 22 August 2017
Publication Date:
14 September 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201719/lookinside/thumbnails/st-2017-s0536-c_10-1055_s-0036-1588568-1.jpg)
Published as part of the Cluster C–O Activation
Abstract
We report a chromium-catalyzed cross-coupling of C–O bonds with widely accessible organic bromides as reactants for the preparation of ortho-arylated or -alkylated aromatic aldehydes at room temperature. The use of metallic magnesium is essential for the reaction to occur, giving it an advantage over previous reactions involving Grignard reagents that have to be prepared separately from organic halides before the coupling.
Key words
chromium - C–O activation - cross-coupling - C–C bond formation - organic bromides - regioselectivitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588568.
- Supporting Information
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References and Notes
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For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
Rh-catalyzed functionalizations of C–O bonds have been recently disclosed by Chatani and co-workers; see:
For examples of cross-coupling reactions using organic halides as reactants mediated by metallic magnesium, see: